@article{10.11648/j.ijgg.20221003.12,
  author = {Hameed Khan},
  title = {The Impact of Sequencing Human Genome on Novel Drug Delivery Method to Treat Cancers},
  journal = {International Journal of Genetics and Genomics},
  volume = {10},
  number = {3},
  pages = {64-78},
  doi = {10.11648/j.ijgg.20221003.12},
  url = {https://doi.org/10.11648/j.ijgg.20221003.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijgg.20221003.12},
  abstract = {Sequencing Human Genome has identified 24,000 genes in our genome. Out of which six- thousand genes are mutated and are responsible for causing six thousand different diseases including old age diseases such as Alzheimer, Cardiovascular Disease and Cancers. Of all the cancers, brain cancer is most difficult to treat. The drug delivery methods require to transport active drugs components from the injection site to the target site. To treat all mental illnesses including brain cancer, the greatest challenge for most scientists is to deliver drug across the natural filter called, the Blood Brain Barrier (BBB). Besides addictive narcotics, most drugs are filtered out by BBB. Of all the cancers, developing drugs to treat brain cancer presents the greatest challenge. Glioblastoma is the solid, aggressive and the deadliest form of brain cancer. Once diagnosed, most patients die within fourteen months of their diagnosis. By making AZQ (US Patent 4,233,215), I have demonstrated, a novel drug delivery method by attaching Quinone, a non-addictive, non-toxic chemical as a carrier, I could deliver prodrug moieties like Aziridines and Carbamates across BBB to attack Glioblastoma, the brain tumor. Once it crosses the BBB, AZQ, a prodrug, remains inactive at natural pH, but it is activated by the growing brain tumor. To grow, the Glioblastoma uses glucose as a source of energy. Glucose is broken down to produce Lactic Acid. In the acidic media, the prodrug moieties Aziridines and Carbamates are activated producing the most powerful Carbonium ions which attack the tumor DNA shutting off the genes. Instead of growing, the Glioblastoma starts shrinking. By making AZQ and using Quinone as a drug delivery chemical across BBB, I opened the path to attack all other mental illnesses such as Epilepsy, Schizophrenia, Bipolar disorder, Depression, Anxiety disorders, Paranoia, Psychosis and Aggression. In future, male and female hormones could be used to deliver active drug components such as aziridines and carbamates to attack Breast and Prostate cancers.},
 year = {2022}
}

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TY  - JOUR
T1  - The Impact of Sequencing Human Genome on Novel Drug Delivery Method to Treat Cancers
AU  - Hameed Khan
Y1  - 2022/07/29
PY  - 2022
N1  - https://doi.org/10.11648/j.ijgg.20221003.12
DO  - 10.11648/j.ijgg.20221003.12
T2  - International Journal of Genetics and Genomics
JF  - International Journal of Genetics and Genomics
JO  - International Journal of Genetics and Genomics
SP  - 64
EP  - 78
PB  - Science Publishing Group
SN  - 2376-7359
UR  - https://doi.org/10.11648/j.ijgg.20221003.12
AB  - Sequencing Human Genome has identified 24,000 genes in our genome. Out of which six- thousand genes are mutated and are responsible for causing six thousand different diseases including old age diseases such as Alzheimer, Cardiovascular Disease and Cancers. Of all the cancers, brain cancer is most difficult to treat. The drug delivery methods require to transport active drugs components from the injection site to the target site. To treat all mental illnesses including brain cancer, the greatest challenge for most scientists is to deliver drug across the natural filter called, the Blood Brain Barrier (BBB). Besides addictive narcotics, most drugs are filtered out by BBB. Of all the cancers, developing drugs to treat brain cancer presents the greatest challenge. Glioblastoma is the solid, aggressive and the deadliest form of brain cancer. Once diagnosed, most patients die within fourteen months of their diagnosis. By making AZQ (US Patent 4,233,215), I have demonstrated, a novel drug delivery method by attaching Quinone, a non-addictive, non-toxic chemical as a carrier, I could deliver prodrug moieties like Aziridines and Carbamates across BBB to attack Glioblastoma, the brain tumor. Once it crosses the BBB, AZQ, a prodrug, remains inactive at natural pH, but it is activated by the growing brain tumor. To grow, the Glioblastoma uses glucose as a source of energy. Glucose is broken down to produce Lactic Acid. In the acidic media, the prodrug moieties Aziridines and Carbamates are activated producing the most powerful Carbonium ions which attack the tumor DNA shutting off the genes. Instead of growing, the Glioblastoma starts shrinking. By making AZQ and using Quinone as a drug delivery chemical across BBB, I opened the path to attack all other mental illnesses such as Epilepsy, Schizophrenia, Bipolar disorder, Depression, Anxiety disorders, Paranoia, Psychosis and Aggression. In future, male and female hormones could be used to deliver active drug components such as aziridines and carbamates to attack Breast and Prostate cancers.
VL  - 10
IS  - 3
ER  - 

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