<I>BAT26</I> Microsatellite Marker Polymorphism in Colorectal Cancer in Senegalese Patients

Seye Yacine; Ndong Anna; Keneme Bineta; Sembene Pape Mbacke

doi:doi:10.11648/j.ijgg.20221003.11

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BAT26 Microsatellite Marker Polymorphism in Colorectal Cancer in Senegalese Patients

Seye Yacine, Ndong Anna, Keneme Bineta, Sembene Pape Mbacke

Published in International Journal of Genetics and Genomics (Volume 10, Issue 3)

Received: 11 June 2022 Accepted: 30 June 2022 Published: 12 July 2022

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Abstract

Colorectal cancer is a serious problem in cancerology due to its frequency and severity. It is the third most common form of cancer, with one million new cases worldwide each year, and its mortality is around 30%. Despite significant advances in "omics" techniques that allow us to understand the molecular mechanisms involved in the evolution of cancer pathologies, the strongest risk factors currently involved in the ethology of this cancer are those of a genetic nature, with specific mutations. The aim of this study is therefore to accurately establish the incidence of the MSI phenotype in Senegalese patients with colorectal cancer using the BAT26 single nucleotide marker. To identify these phenotypes, the BAT26 loci sequences of 18 cancer patients were compared with a reference sequence and their haplotypes were determined through DnaSP version 5.10. The MEGA software version 7.014 and the Arlequin program version 3.1 were used to highlight the genetic differentiation as well as the demo-genetic evolution of our study populations. The results of this comparison revealed a high microsatellite instability. This nucleotide difference is materialized by adenine to guanine substitutions present in the sequences of 17 cancer patients. This variability between cancer tissues is confirmed by the Nei genetic distance which shows that cancer tissues are genetically heterogeneous. The Fst indicates that there is genetic structuring between the cancer tissue sequences and our control (the reference sequence). These results suggest that this polymorphism of the BAT26 single-nucleotide marker may be involved in the occurrence of this cancer.

Published in	International Journal of Genetics and Genomics (Volume 10, Issue 3)
DOI	10.11648/j.ijgg.20221003.11
Page(s)	59-63
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

BAT26, Colorectal Cancer, Instability, Microsatellite, Variability

References

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APA Style

Seye Yacine, Ndong Anna, Keneme Bineta, Sembene Pape Mbacke. (2022). BAT26 Microsatellite Marker Polymorphism in Colorectal Cancer in Senegalese Patients. International Journal of Genetics and Genomics, 10(3), 59-63. https://doi.org/10.11648/j.ijgg.20221003.11

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ACS Style

Seye Yacine; Ndong Anna; Keneme Bineta; Sembene Pape Mbacke. BAT26 Microsatellite Marker Polymorphism in Colorectal Cancer in Senegalese Patients. Int. J. Genet. Genomics 2022, 10(3), 59-63. doi: 10.11648/j.ijgg.20221003.11

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AMA Style

Seye Yacine, Ndong Anna, Keneme Bineta, Sembene Pape Mbacke. BAT26 Microsatellite Marker Polymorphism in Colorectal Cancer in Senegalese Patients. Int J Genet Genomics. 2022;10(3):59-63. doi: 10.11648/j.ijgg.20221003.11

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@article{10.11648/j.ijgg.20221003.11,
  author = {Seye Yacine and Ndong Anna and Keneme Bineta and Sembene Pape Mbacke},
  title = {BAT26 Microsatellite Marker Polymorphism in Colorectal Cancer in Senegalese Patients},
  journal = {International Journal of Genetics and Genomics},
  volume = {10},
  number = {3},
  pages = {59-63},
  doi = {10.11648/j.ijgg.20221003.11},
  url = {https://doi.org/10.11648/j.ijgg.20221003.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijgg.20221003.11},
  abstract = {Colorectal cancer is a serious problem in cancerology due to its frequency and severity. It is the third most common form of cancer, with one million new cases worldwide each year, and its mortality is around 30%. Despite significant advances in "omics" techniques that allow us to understand the molecular mechanisms involved in the evolution of cancer pathologies, the strongest risk factors currently involved in the ethology of this cancer are those of a genetic nature, with specific mutations. The aim of this study is therefore to accurately establish the incidence of the MSI phenotype in Senegalese patients with colorectal cancer using the BAT26 single nucleotide marker. To identify these phenotypes, the BAT26 loci sequences of 18 cancer patients were compared with a reference sequence and their haplotypes were determined through DnaSP version 5.10. The MEGA software version 7.014 and the Arlequin program version 3.1 were used to highlight the genetic differentiation as well as the demo-genetic evolution of our study populations. The results of this comparison revealed a high microsatellite instability. This nucleotide difference is materialized by adenine to guanine substitutions present in the sequences of 17 cancer patients. This variability between cancer tissues is confirmed by the Nei genetic distance which shows that cancer tissues are genetically heterogeneous. The Fst indicates that there is genetic structuring between the cancer tissue sequences and our control (the reference sequence). These results suggest that this polymorphism of the BAT26 single-nucleotide marker may be involved in the occurrence of this cancer.},
 year = {2022}
}

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TY  - JOUR
T1  - BAT26 Microsatellite Marker Polymorphism in Colorectal Cancer in Senegalese Patients
AU  - Seye Yacine
AU  - Ndong Anna
AU  - Keneme Bineta
AU  - Sembene Pape Mbacke
Y1  - 2022/07/12
PY  - 2022
N1  - https://doi.org/10.11648/j.ijgg.20221003.11
DO  - 10.11648/j.ijgg.20221003.11
T2  - International Journal of Genetics and Genomics
JF  - International Journal of Genetics and Genomics
JO  - International Journal of Genetics and Genomics
SP  - 59
EP  - 63
PB  - Science Publishing Group
SN  - 2376-7359
UR  - https://doi.org/10.11648/j.ijgg.20221003.11
AB  - Colorectal cancer is a serious problem in cancerology due to its frequency and severity. It is the third most common form of cancer, with one million new cases worldwide each year, and its mortality is around 30%. Despite significant advances in "omics" techniques that allow us to understand the molecular mechanisms involved in the evolution of cancer pathologies, the strongest risk factors currently involved in the ethology of this cancer are those of a genetic nature, with specific mutations. The aim of this study is therefore to accurately establish the incidence of the MSI phenotype in Senegalese patients with colorectal cancer using the BAT26 single nucleotide marker. To identify these phenotypes, the BAT26 loci sequences of 18 cancer patients were compared with a reference sequence and their haplotypes were determined through DnaSP version 5.10. The MEGA software version 7.014 and the Arlequin program version 3.1 were used to highlight the genetic differentiation as well as the demo-genetic evolution of our study populations. The results of this comparison revealed a high microsatellite instability. This nucleotide difference is materialized by adenine to guanine substitutions present in the sequences of 17 cancer patients. This variability between cancer tissues is confirmed by the Nei genetic distance which shows that cancer tissues are genetically heterogeneous. The Fst indicates that there is genetic structuring between the cancer tissue sequences and our control (the reference sequence). These results suggest that this polymorphism of the BAT26 single-nucleotide marker may be involved in the occurrence of this cancer.
VL  - 10
IS  - 3
ER  -

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Author Information

Seye Yacine

Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, Dakar, Senegal
Ndong Anna

Department of Animal Biology, Cheikh Anta Diop University, Dakar, Senegal
Keneme Bineta

Department of Animal Biology, Cheikh Anta Diop University, Dakar, Senegal
Sembene Pape Mbacke

Department of Animal Biology, Cheikh Anta Diop University, Dakar, Senegal

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APA Style

Seye Yacine, Ndong Anna, Keneme Bineta, Sembene Pape Mbacke. (2022). BAT26 Microsatellite Marker Polymorphism in Colorectal Cancer in Senegalese Patients. International Journal of Genetics and Genomics, 10(3), 59-63. https://doi.org/10.11648/j.ijgg.20221003.11

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ACS Style

Seye Yacine; Ndong Anna; Keneme Bineta; Sembene Pape Mbacke. BAT26 Microsatellite Marker Polymorphism in Colorectal Cancer in Senegalese Patients. Int. J. Genet. Genomics 2022, 10(3), 59-63. doi: 10.11648/j.ijgg.20221003.11

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AMA Style

Seye Yacine, Ndong Anna, Keneme Bineta, Sembene Pape Mbacke. BAT26 Microsatellite Marker Polymorphism in Colorectal Cancer in Senegalese Patients. Int J Genet Genomics. 2022;10(3):59-63. doi: 10.11648/j.ijgg.20221003.11

Copy | Download

@article{10.11648/j.ijgg.20221003.11,
  author = {Seye Yacine and Ndong Anna and Keneme Bineta and Sembene Pape Mbacke},
  title = {BAT26 Microsatellite Marker Polymorphism in Colorectal Cancer in Senegalese Patients},
  journal = {International Journal of Genetics and Genomics},
  volume = {10},
  number = {3},
  pages = {59-63},
  doi = {10.11648/j.ijgg.20221003.11},
  url = {https://doi.org/10.11648/j.ijgg.20221003.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijgg.20221003.11},
  abstract = {Colorectal cancer is a serious problem in cancerology due to its frequency and severity. It is the third most common form of cancer, with one million new cases worldwide each year, and its mortality is around 30%. Despite significant advances in "omics" techniques that allow us to understand the molecular mechanisms involved in the evolution of cancer pathologies, the strongest risk factors currently involved in the ethology of this cancer are those of a genetic nature, with specific mutations. The aim of this study is therefore to accurately establish the incidence of the MSI phenotype in Senegalese patients with colorectal cancer using the BAT26 single nucleotide marker. To identify these phenotypes, the BAT26 loci sequences of 18 cancer patients were compared with a reference sequence and their haplotypes were determined through DnaSP version 5.10. The MEGA software version 7.014 and the Arlequin program version 3.1 were used to highlight the genetic differentiation as well as the demo-genetic evolution of our study populations. The results of this comparison revealed a high microsatellite instability. This nucleotide difference is materialized by adenine to guanine substitutions present in the sequences of 17 cancer patients. This variability between cancer tissues is confirmed by the Nei genetic distance which shows that cancer tissues are genetically heterogeneous. The Fst indicates that there is genetic structuring between the cancer tissue sequences and our control (the reference sequence). These results suggest that this polymorphism of the BAT26 single-nucleotide marker may be involved in the occurrence of this cancer.},
 year = {2022}
}

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TY  - JOUR
T1  - BAT26 Microsatellite Marker Polymorphism in Colorectal Cancer in Senegalese Patients
AU  - Seye Yacine
AU  - Ndong Anna
AU  - Keneme Bineta
AU  - Sembene Pape Mbacke
Y1  - 2022/07/12
PY  - 2022
N1  - https://doi.org/10.11648/j.ijgg.20221003.11
DO  - 10.11648/j.ijgg.20221003.11
T2  - International Journal of Genetics and Genomics
JF  - International Journal of Genetics and Genomics
JO  - International Journal of Genetics and Genomics
SP  - 59
EP  - 63
PB  - Science Publishing Group
SN  - 2376-7359
UR  - https://doi.org/10.11648/j.ijgg.20221003.11
AB  - Colorectal cancer is a serious problem in cancerology due to its frequency and severity. It is the third most common form of cancer, with one million new cases worldwide each year, and its mortality is around 30%. Despite significant advances in "omics" techniques that allow us to understand the molecular mechanisms involved in the evolution of cancer pathologies, the strongest risk factors currently involved in the ethology of this cancer are those of a genetic nature, with specific mutations. The aim of this study is therefore to accurately establish the incidence of the MSI phenotype in Senegalese patients with colorectal cancer using the BAT26 single nucleotide marker. To identify these phenotypes, the BAT26 loci sequences of 18 cancer patients were compared with a reference sequence and their haplotypes were determined through DnaSP version 5.10. The MEGA software version 7.014 and the Arlequin program version 3.1 were used to highlight the genetic differentiation as well as the demo-genetic evolution of our study populations. The results of this comparison revealed a high microsatellite instability. This nucleotide difference is materialized by adenine to guanine substitutions present in the sequences of 17 cancer patients. This variability between cancer tissues is confirmed by the Nei genetic distance which shows that cancer tissues are genetically heterogeneous. The Fst indicates that there is genetic structuring between the cancer tissue sequences and our control (the reference sequence). These results suggest that this polymorphism of the BAT26 single-nucleotide marker may be involved in the occurrence of this cancer.
VL  - 10
IS  - 3
ER  -

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